| Manchester United – Ipswich |
30. aug. 15:30 |
| Everton – Manchester United |
06. sep. 13:00 |
| Sporting CP – Manchester United |
08. sep. 19:00 |
| Manchester United – Bayern München |
08. sep. 19:00 |
| Manchester United – RB Leipzig |
08. sep. 19:00 |
| Manchester United – AS Roma |
08. sep. 19:00 |
| Manchester United – Sabah FA |
08. sep. 19:00 |
| Atletico Madrid – Manchester United |
08. sep. 19:00 |
| Como – Manchester United |
08. sep. 19:00 |
| Villarreal – Manchester United |
08. sep. 19:00 |
| Manchester United – Manchester City |
13. sep. 15:30 |
| Fulham – Manchester United |
20. sep. 15:30 |
| Manchester United – Tottenham |
10. okt. 16:30 |
| Leeds – Manchester United |
18. okt. 13:00 |
| Manchester United – Bournemouth |
25. okt. 14:00 |
| Chelsea – Manchester United |
31. okt. 12:30 |
| Manchester United – Aston Villa |
07. nov. 15:00 |
| Liverpool – Manchester United |
21. nov. 15:00 |
| Manchester United – Brentford |
28. nov. 15:00 |
| Newcastle – Manchester United |
02. dec. 20:00 |
| Manchester United – Coventry |
05. dec. 15:00 |
| Crystal Palace – Manchester United |
12. dec. 15:00 |
| Arsenal – Manchester United |
19. dec. 15:00 |
| Manchester United – Nottingham Forest |
26. dec. 15:00 |
| Manchester United – Sunderland |
30. dec. 20:00 |
| Brighton – Manchester United |
02. jan. 15:00 |
| Manchester United – Newcastle |
06. jan. 20:00 |
| Aston Villa – Manchester United |
16. jan. 15:00 |
| Manchester United – Liverpool |
23. jan. 15:00 |
| Brentford – Manchester United |
30. jan. 15:00 |
| Manchester United – Chelsea |
06. feb. 15:00 |
| Manchester United – Brighton |
10. feb. 20:00 |
| Nottingham Forest – Manchester United |
20. feb. 15:00 |
| Manchester United – Arsenal |
27. feb. 15:00 |
| Sunderland – Manchester United |
03. mar. 20:00 |
| Manchester United – Everton |
13. mar. 15:00 |
| Manchester City – Manchester United |
20. mar. 15:00 |
| Manchester United – Hull City |
10. apr. 14:00 |
| Ipswich – Manchester United |
17. apr. 14:00 |
| Manchester United – Crystal Palace |
24. apr. 14:00 |
| Coventry – Manchester United |
01. maj 14:00 |
| Bournemouth – Manchester United |
08. maj 14:00 |
| Manchester United – Leeds |
15. maj 14:00 |
| Tottenham – Manchester United |
23. maj 14:00 |
| Manchester United – Fulham |
30. maj 15:00 |
